ABSTRACT
Background: Glioblastoma [U-87] is the most common and most malignant of the glial tumors that appeared in the central nervous system. This is the first study that has evaluated the cytotoxic effects of various Girard-P reagent-based Schiff bases and their dimethyltin [IV] complexes on Glioblastoma cell line, U-87, viability
Materials and methods: In this experimental study, U-87 cell line was grown in DMEM supplemented with 10% FBS, penicillin/streptomycin [100 U/ml, 100 micro.g/ml] at 37 °C in 5% CO2, then the effects of different concentrations of complexes on Glioblastoma cell were evaluated by MTT and DAPI staining
Results: Herein, we demonstrated that these compounds had cytotoxicity effects of Glioblastoma cancer cells. In a dose dependent manner, a significant cytotoxicity was observed with increasing of PlMandP3
Conclusion: The results showed that Girard-P reagent-based Schiff bases and their dimethyltin [IV] complexes have the ability to induce cytotoxicity in the Glioblastoma cancer cell line in lower mg/ml concentrations. In conclusion, these findings may introduce a new view on the mode of action and possible application of new compounds in the cancer chemotherapy